327 research outputs found
Using geographically weighted regression to explore the spatially heterogeneous spread of bovine tuberculosis in England and Wales
An understanding of the factors that affect the spread of endemic bovine tuberculosis (bTB) is critical for the development of measures to stop and reverse this spread. Analyses of spatial data need to account for the inherent spatial heterogeneity within the data, or else spatial autocorrelation can lead to an overestimate of the significance of variables. This study used three methods of analysis—least-squares linear regression with a spatial autocorrelation term, geographically weighted regression (GWR) and boosted regression tree (BRT) analysis—to identify the factors that influence the spread of endemic bTB at a local level in England and Wales. The linear regression and GWR methods demonstrated the importance of accounting for spatial differences in risk factors for bTB, and showed some consistency in the identification of certain factors related to flooding, disease history and the presence of multiple genotypes of bTB. This is the first attempt to explore the factors associated with the spread of endemic bTB in England and Wales using GWR. This technique improves on least-squares linear regression approaches by identifying regional differences in the factors associated with bTB spread. However, interpretation of these complex regional differences is difficult and the approach does not lend itself to predictive models which are likely to be of more value to policy makers. Methods such as BRT may be more suited to such a task. Here we have demonstrated that GWR and BRT can produce comparable outputs
Mid-Infrared Evidence for Accelerated Evolution in Compact Group Galaxies
We find evidence for accelerated evolution in compact group galaxies from the
distribution in mid-infrared colorspace of 42 galaxies from 12 Hickson Compact
Groups (HCGs) compared to the the distributions of several other samples
including the LVL+SINGS galaxies, interacting galaxies, and galaxies from the
Coma Cluster. We find that the HCG galaxies are not uniformly distributed in
colorspace, as well as quantitative evidence for a gap. Galaxies in the infall
region of the Coma cluster also exhibit a non-uniform distribution and a less
well defined gap, which may reflect a similarity with the compact group
environment. Neither the Coma Center or interacting samples show evidence of a
gap, leading us to speculate that the gap is unique to the environment of high
galaxy density where gas has not been fully processed or stripped.Comment: To appear in the Proceedings of the Galaxy Wars: Stellar Populations
and Star Formation in Interacting Galaxies Conferenc
An Exploration of the Patient Lived Experience of Remission and Relapse of Type 2 Diabetes Following Bariatric Surgery
BACKGROUND: Bariatric surgery is the most effective treatment for patients with obesity and type 2 diabetes (T2DM), inducing profound metabolic changes associated with improvements in glycaemic control. In spite of the recognition of the physiological changes associated with bariatric surgery, what remains underappreciated is the patient experience of surgery to treat T2DM. OBJECTIVES: This study explored the patient experience with regard to motivations, expectations and outcomes, including remission and relapse of diabetes. METHODS: An in-depth qualitative approach was adopted, encompassing semi-structured interviews with patients (n=17) living with obesity and T2DM both pre- and postsurgery. Interpretive thematic analysis identified emergent themes using a grounded approach. RESULTS: Analysis revealed a number of themes throughout the interviews which included motivations and perceived benefits of surgery, obesity stigma and its impact on self-worth as well as perceptions of remission or relapse and the implications for sense of control. CONCLUSIONS: The motivation for undergoing bariatric surgery was driven by health concerns, namely T2DM and the desire to reduce the risk of developing diabetes-related complications. Patients highlighted social and self-stigmatisation associated with obesity and T2DM, leading to feelings of shame and an inability to seek support from family or healthcare professionals. Stigmatisation created a sense of failure and feeling of guilt for having T2DM. As a result, patients felt responsible for maintaining disease remission postoperatively and regarded the need for medication as a sign of treatment failure
Klebsiella pneumoniae is able to trigger epithelial-mesenchymal transition process in cultured airway epithelial cells
The ability of some bacterial pathogens to activate Epithelial-Mesenchymal Transition normally is a consequence of the persistence of a local chronic inflammatory response or depends on a direct interaction of the pathogens with the host epithelial cells. In this study we monitored the abilities of the K. pneumoniae to activate the expression of genes related to EMT-like processes and the occurrence of phenotypic changes in airway epithelial cells during the early steps of cell infection. We describe changes in the production of intracellular reactive oxygen species and increased HIF-1α mRNA expression in cells exposed to K. pneumoniae infection. We also describe the upregulation of a set of transcription factors implicated in the EMT processes, such as Twist, Snail and ZEB, indicating that the morphological changes of epithelial cells already appreciable after few hours from the K. pneumoniae infection are tightly regulated by the activation of transcriptional pathways, driving epithelial cells to EMT. These effects appear to be effectively counteracted by resveratrol, an antioxidant that is able to exert a sustained scavenging of the intracellular ROS. This is the first report indicating that strains of K. pneumoniae may promote EMT-like programs through direct interaction with epithelial cells without the involvement of inflammatory cells
The morphologies and masses of extremely red galaxies in the Groth Strip survey
We present a new cataloge of EROs from the Groth strip and study the relation
between their morphology and mass. We find 102 EROs (F814W-K=>4, K<=21.0), over
a survey area of 155 arcmin^2. The photometric data include U,B,F606W,F814W,J,K
bands. Morphologies are based on a by eye classification and we distinguish
between 3 basic classes: compact objects, targets with a disc and/or a bulge
component and irregular or merger candidates. The majority of our targets has
either a very compact morphology (33+-6%), or show more or less distinct disc
components (41+-6%). 14+-4% are merger or irregulars and 7 objects could not be
classified. We also study the dependence of structural parameters on
morphological appearance. EROs that are either compact or show a distinct bulge
component have smaller median effective radii (1.22+-0.14 kpc and 3.31+-0.53
kpc) than disc dominated (5.50+-0.51 kpc) or possible irregular galaxies or
merger candidates (4.92+-0.14 kpc). The Sersic index changes from 2.30+-0.34
and 3.24+-0.55, to 1.03+-0.24 and 1.54+-0.40 respectively.
Most the EROs in our sample have redshifts between z=1 and z=2; however,
compact EROs in our sample are found at redshifts as low as z=0.4 and as high
as z=2.8; the latter qualify as well as DRGs. Disc-like EROs are also found up
to z=2.8; however those with a bulge-disc structure are only seen at z<1.5. For
each of these EROs we determined the stellar mass and mean population age by
fitting synthetic Bruzual (2007) spectra to the SED. Mass estimates were
obtained by assuming an exponentially declining star formation rate. Total
stellar masses are in the range 9.1<log(M/M_sun)<11.6. We cannot detect
significant differences between the stellar mass distribution of the
morphological classes. EROs with masses of log(M/M_sun)>11.0 dominantly show
compact morphologies, but also include a significant number of sources with a
disc morphology.Comment: 21 pages, 17 figures, accepted for publication in MNRA
The Galaxy Structure-Redshift Relationship
There exists a gradual, but persistent, evolutionary effect in the galaxy
population such that galaxy structure and morphology change with redshift. This
galaxy structure-redshift relationship is such that an increasingly large
fraction of all bright and massive galaxies at redshifts 2 < z < 3 are
morphologically peculiar at wavelengths from rest-frame ultraviolet to
rest-frame optical. There are however examples of morphologically selected
spirals and ellipticals at all redshifts up to z ~ 3. At lower redshift, the
bright galaxy population smoothly transforms into normal ellipticals and
spirals. The rate of this transformation strongly depends on redshift, with the
swiftest evolution occurring between 1 < z < 2. This review characterizes the
galaxy structure-redshift relationship, discusses its various physical causes,
and how these are revealing the mechanisms responsible for galaxy formation.Comment: 20 pages, 8 figures. Invited Review to appear in "Penetrating Bars
Through Masks of Cosmic Dust: The Hubble Tuning Fork Strikes A New Note", ed.
D. Block et a
The COSMOS AGN Spectroscopic Survey I: XMM Counterparts
We present optical spectroscopy for an X-ray and optical flux-limited sample
of 677 XMM-Newton selected targets covering the 2 deg^2 COSMOS field, with a
yield of 485 high-confidence redshifts. The majority of the spectra were
obtained over three seasons (2005-2007) with the IMACS instrument on the
Magellan (Baade) telescope. We also include in the sample previously published
Sloan Digital Sky Survey spectra and supplemental observations with
MMT/Hectospec. We detail the observations and classification analyses. The
survey is 90% complete to flux limits of f_{0.5-10 keV}>8 x 10^-16 erg cm^-2
s^-1 and i_AB+<22, where over 90% of targets have high-confidence redshifts.
Making simple corrections for incompleteness due to redshift and spectral type
allows for a description of the complete population to $i_AB+<23. The corrected
sample includes 57% broad emission line (Type 1, unobscured) AGN at
0.13<z<4.26, 25% narrow emission line (Type 2, obscured) AGN at 0.07<z<1.29,
and 18% absorption line (host-dominated, obscured) AGN at 0<z<1.22 (excluding
the stars that made up 4% of the X-ray targets). We show that the survey's
limits in X-ray and optical flux include nearly all X-ray AGN (defined by
L_{0.5-10 keV}>3 x 10^42 erg s^-1) to z<1, of both optically obscured and
unobscured types. We find statistically significant evidence that the obscured
to unobscured AGN ratio at z<1 increases with redshift and decreases with
luminosity.Comment: Accepted for publication in the ApJ. 31 pages, 17 figures. Table 2 is
available on reques
Connecting the cosmic infrared background to the X-ray background
We estimate the contribution of AGNs and of their host galaxies to the
infrared background. We use the luminosity function and evolution of AGNs
recently determined by the hard X-ray surveys, and new Spectral Energy
Distributions connecting the X-ray and the infrared emission, divided in
intervals of absorption. These two ingredients allow us to determine the
contribution of AGNs to the infrared background by using mostly observed
quantities, with only minor assumptions. We obtain that AGN emission
contributes little to the infrared background (5% over most of the infrared
bands), implying that the latter is dominated by star formation. However, AGN
host galaxies may contribute significantly to the infrared background, and more
specifically 10--20% in the 1--20m range and 5% at . We also give the contribution of AGNs and of their host galaxies to the
source number counts in various infrared bands, focusing on those which will be
observed with Spitzer. We also report a significant discrepancy between the
expected contribution of AGN hosts to the submm background and bright submm
number counts with the observational constraints. We discuss the causes and
implications of this discrepancy and the possible effects on the Spitzer far-IR
bands.Comment: to appear in MNRAS, replaced with accepted version, paper shortened,
results unchange
The starburst-AGN connection in the merger galaxy Mrk 938: an infrared and X-ray view
Mrk938 is a luminous infrared galaxy in the local Universe believed to be the
remnant of a galaxy merger. It shows a Seyfert 2 nucleus and intense star
formation according to optical spectroscopic observations. We have studied this
galaxy using new Herschel far-IR imaging data in addition to archival X-ray,
UV, optical, near-IR and mid-IR data. Mid- and far-IR data are crucial to
characterise the starburst contribution, allowing us to shed new light on its
nature and to study the coexistence of AGN and starburst activity in the local
Universe. The decomposition of the mid-IR Spitzer spectrum shows that the AGN
bolometric contribution to the mid-IR and total infrared luminosity is small
(Lbol(AGN)/LIR~0.02), which agrees with previous estimations. We have
characterised the physical nature of its strong infrared emission and
constrained it to a relatively compact emitting region of <2kpc. It is in this
obscured region where most of the current star formation activity is taking
place as expected for LIRGs. We have used Herschel imaging data for the first
time to constrain the cold dust emission with unprecedented accuracy. We have
fitted the integrated far-IR spectral energy distribution and derived the
properties of the dust, obtaining a dust mass of 3x10^7Msun. The far-IR is
dominated by emission at 35K, consistent with dust heated by the on-going star
formation activity.Comment: 12 pages, 6 figures, 4 tables, accepted for publication in MNRA
Intrinsic alignment as an RSD contaminant in the DESI survey
We measure the tidal alignment of the major axes of luminous red galaxies (LRGs) from the Legacy Imaging Survey and use it to infer the artificial redshift-space distortion signature that will arise from an orientation-dependent, surface-brightness selection in the Dark Energy Spectroscopic Instrument (DESI) survey. Using photometric redshifts to downweight the shape–density correlations due to weak lensing, we measure the intrinsic tidal alignment of LRGs. Separately, we estimate the net polarization of LRG orientations from DESI’s fibre-magnitude target selection to be of order 10-2 along the line of sight. Using these measurements and a linear tidal model, we forecast a 0.5 per cent fractional decrease on the quadrupole of the two-point correlation function for projected separations of 40–80 h-1 Mpc. We also use a halo catalogue from the ABACUSSUMMIT cosmological simulation suite to reproduce this false quadrupole
- …